منابع مشابه
Clinical relevance of P-glycoprotein expression in haematological malignancies.
Although, generally speaking, haematological malignancies are chemotherapy-responsive tumours and high remission induction rates are obtained, disease-related death is the rule rather than the exception. The appearance of cell populations, resistant to multidrug-based chemotherapy, constitutes the major problem to achieve cures in these patients. Advances in cell biology have partly contributed...
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(w ww .m ed kn ow .co m) . Monoclonal antibodies (MAbs), a new class of biological agents, are used these days in therapeutics and diagnosis. MAbs also labeled as ‘magic bullets’, are highly specific Department of Pharmacology, antibodies produced by a clone of single hybrid cells formed in the laboratory by fusion Christian Medical College and of B cell with the tumor cell. The hybridoma forme...
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It was recently shown that naturally occurring Mdr1a mutant fetuses of the CF-1 outbred mouse stock have no placental Mdr1a P-glycoprotein (P-gp) and that this absence is associated with increased sensitivity to avermectin, a teratogenic pesticide. To further define the role of placental drug-transporting P-gp in toxicological protection of the fetus, we used mice with a targeted disruption of ...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2006
ISSN: 0253-7613
DOI: 10.4103/0253-7613.19847